Porous membranes are intended on separation of larger molecules such as solid colloidal particles, large biomolecules (proteins, DNA, RNA) and cells from the filtering media and they are used in microfiltration, ultrafiltration, and dialysis applications. Usually we imagine membrane pores like parallel, nonintersecting cylindrical capillaries, in reality the pores structure could be a random network of the unevenly shaped structures of different sizes. The 3D Cell Explorer can be used to obtain crucial morphological information about their structure, thanks to a marker free, real-time 3D reconstruction. 

Glass membrane
Polycarbonate membrane

One of the most prevalent types of CTC (Circulating Tumor Cell) enrichment technique is the filtration method. Those methods are based on physical properties that allow isolation of CTCs by size. Indeed, CTCs are generally larger in size than hematopoietic cells, so most of these cells pass through the filter whereas CTCs are retained.

The size-based isolation of CTCs was initially explored by using polycarbonate filters. Here is presented the acquisition of one of these filters.  


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